Premazzi attended the Brera Academy of Fine Arts and then the private school run by Giovanni Migliara. His early watercolours, based on the works of his master, were produced for the lithographic industry. His oeuvre is characterised by a repertoire of urban views produced in accordance with the dictates of perspective painting. While most of these are set in Milan, other Italian cities were also featured in later years. His smooth, precise painting also shows the influence of his contemporary Luigi Bisi in its descriptive focus on architectural detail. He presented work regularly at the exhibitions of the Società Promotrice di Belle Arti in Turin from 1842 to 1848 as well as those of the Brera Academy. Having moved to Saint Petersburg around 1850, he became a teacher at the Imperial School of Fine Arts there in 1861. Frequent stays in the Caucasus and the Middle East provided new subjects for his paintings, which he continued to send to Italian exhibitions, where they aroused wonder and curiosity.