Spadini worked as a ceramist in Florence and attended the school of nude studies at the Academy of Fine Arts, where he met Ardengo Soffici, as from 1900. Introduced to the Symbolist magazine Leonardo in 1902, he took part in the 59th Esposizione Annuale della Società delle Belle Arti di Firenze in 1906. He moved to Rome in 1910 and devoted his energies to portraits and views of the city. His participation in the Esposizione Internazionale della Secessione began with the first in 1913 and continued in subsequent editions, with one of his works being purchased by the Rome City Council at the fourth (1916). He went through a difficult period after World War I and was attacked as a conservative in the magazine Valori Plastici. The decision of the Venice Biennale to devote a room exclusively to Spadini’s work at the 14th Esposizione Internazionale d’Arte della Città di Venezia in 1924 marked the end of this hostility and the definitive success of his painting.