Trained as a painter and ceramist by his father Basilio in Pescara, Cascella made his debut in 1907 with pastels in the realistic style at the Famiglia Artistica in Milan. Involved in a whole variety of exhibitions from the very outset, he also presented his late-Divisionist works in Paris at the Galerie Druet (1909) and the Salon d’Automne (1910). After serving in World War I, he began to produce works in a more illustrative style. He moved to Milan in 1920 and took part in the Venice Biennale of 1924 (14th Esposizione Internazionale d’Arte di Venezia). His international reputation grew in the 1930s and works were purchased by the Musée Jeu-de-Paume in Paris (1930), the Victoria and Albert Museum in London (1931) and the Galleria Mussolini (now the Galleria Nazionale d’Arte Moderna) in Rome (1930). His celebrated views of Portofino were in great demand with private collectors in the years after World War II.